NOP a process's functions in VB .net?

[PiZZAMiN]

[PR ID] Program.exe!Program.exe+0x3E300 || [0x0043E300] || Custom Patch [6 Bytes] || mov edx , dword ptr [esp+04h] || nop
[PR ID] Program.exe!Program.exe+0x3E360 || [0x0043E360] || Custom Patch [7 Bytes] || push esi                      || nop
[PR ID] Program.exe!Program.exe+0x3E940 || [0x0043E940] || Custom Patch [6 Bytes] || push ebx                      || nop
[PR ID] Program.exe!Program.exe+0x75BD0 || [0x00475BD0] || Custom Patch [8 Bytes] || sub esp , 40h  || nop

How can I inject this into the process? It needs to be loaded when the user wants, and the patchmydata won't load if these patches are in the exe eg. i open it and in olly do save to exe with patches then load it crashes. There is no other solution except to do it at a random time. I also want to make sure to have it as a separate exe, as thats what I need to pm them. SO... can anyone make an example? Or is this impossible? Thanks in advance and thanks for reading!

[atom0s]

Import WriteProcessMemory and write the array to the target process:
/>http://www.pinvoke.net/default.aspx/kernel32.writeprocessmemory

You can get a valid handle to use from the Process namespace rather then bothering with OpenProcess:
/>http://msdn.microsoft.com/en-us/library/system.diagnostics.process.aspx

[PiZZAMiN]

Import WriteProcessMemory and write the array to the target process:
/>http://www.pinvoke.net/default.aspx/kernel32.writeprocessmemory

You can get a valid handle to use from the Process namespace rather then bothering with OpenProcess:
/>http://msdn.microsoft.com/en-us/library/system.diagnostics.process.aspx

So how would I for example change the function at 0045B87 to NOP?